Sr. Research Scientist (DMPK) @ Jubilant Life Sciences

Key Responsibilities:

• Responsible for drug metabolism and pharmacokinetic support for discovery programs.
• Support preclinical bioanalysis
• Monitor Pharmacokinetics studies and support bioanalysis
• Providing pre-clinical ADME lead optimization support to small molecule Drug Discovery programs (Hit Identification to Clinical Candidate Selection) including Inflammation, Neuroscience, Metabolic Disorders and Anti-infective Research.
• Working as a DMPK subject matter lead in multidisciplinary/cross functional teams of drug discovery projects.
• Understand the Chemical Structure - ADME relationships and design apt strategies towards improving Drug like Properties of the New Chemical Entities.
• Understand the broader ADME requirements of various projects
• Conduct PK and PK/PD analysis through early pre-clinical development, and collaborate in PK/PD and efficacy study designs
• Collaborate with safety assessment group (in need basis) on study design
• Design tailor made ADME protocols for various projects
• Collate the obtained results and prepare presentations for internal and external meetings
• Contribute to the design of the critical path for various projects
• Prediction of human pharmacokinetic properties from in vitro and in vivo data
• Managing PK and PK/PD analysis through early pre-clinical development, and collaborates in PK/PD and efficacy study design developing robust PK/PD models
• Prediction of human pharmacokinetic properties from in vitro and in vivo data in preclinical species.
• Collaborates with safety assessment group on study design.
• Method validations and analytical trouble shooting; Data generation, compilation, report preparation; Lab note book, record keeping; SOP writing